Prolyl carboxypeptidase in Agouti-related Peptide neurons modulates food intake and body weight
نویسندگان
چکیده
منابع مشابه
PDK1-Foxo1 in Agouti-Related Peptide Neurons Regulates Energy Homeostasis by Modulating Food Intake and Energy Expenditure
Insulin and leptin intracellular signaling pathways converge and act synergistically on the hypothalamic phosphatidylinositol-3-OH kinase/3-phosphoinositide-dependent protein kinase 1 (PDK1). However, little is known about whether PDK1 in agouti-related peptide (AGRP) neurons contributes to energy homeostasis. We generated AGRP neuron-specific PDK1 knockout (AGRPPdk1(-/-)) mice and mice with se...
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Introduction: Gonadotropin inhibitory hormone (GnIH) and Agouti-related peptide (AgRP) are orexigenic peptides expressed in the arcuate nucleus (Arc) of the hypothalamus in the ewe. In addition, effects of GnIH and AgRP on the regulation of gonadotropin releasing hormone secretion have been shown in some mammals. The objective of the present study was to investigate the coexpression of GnIH ...
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ژورنال
عنوان ژورنال: Molecular Metabolism
سال: 2018
ISSN: 2212-8778
DOI: 10.1016/j.molmet.2018.02.003